{"id":10143,"date":"2025-06-12T03:08:51","date_gmt":"2025-06-11T19:08:51","guid":{"rendered":"https:\/\/www.shorro.cn\/index.php\/archives\/10143"},"modified":"2025-06-12T03:08:51","modified_gmt":"2025-06-11T19:08:51","slug":"%e5%88%86%e6%9e%90dbu%e5%af%b9%e7%94%b2%e8%8b%af%e7%a3%ba%e9%85%b8%e7%9b%90%e7%9a%84%e5%82%ac%e5%8c%96%e6%95%88%e7%8e%87%e4%b8%8e%e7%94%a8%e9%87%8f%e4%bc%98%e5%8c%96","status":"publish","type":"post","link":"https:\/\/www.shorro.cn\/index.php\/archives\/10143","title":{"rendered":"\u5206\u6790DBU\u5bf9\u7532\u82ef\u78fa\u9178\u76d0\u7684\u50ac\u5316\u6548\u7387\u4e0e\u7528\u91cf\u4f18\u5316"},"content":{"rendered":"<h1>DBU\u5bf9\u78fa\u9178\u76d0\u7684\u50ac\u5316\u6548\u7387\u4e0e\u7528\u91cf\u4f18\u5316\u7814\u7a76<\/h1>\n<h2>\u5f15\u8a00\uff1a\u4ece\u201c\u50ac\u5316\u5242\u201d\u8bf4\u8d77<\/h2>\n<p>\u5728\u5316\u5b66\u53cd\u5e94\u7684\u4e16\u754c\u91cc\uff0c\u50ac\u5316\u5242\u5c31\u50cf\u662f\u90a3\u4e2a\u603b\u80fd\u5728\u5173\u952e\u65f6\u523b\u62c9\u4f60\u4e00\u628a\u7684\u8001\u670b\u53cb\u2014\u2014\u5b83\u4e0d\u76f4\u63a5\u53c2\u4e0e\u53cd\u5e94\uff0c\u5374\u80fd\u8ba9\u6574\u4e2a\u8fc7\u7a0b\u5feb\u5f97\u50cf\u5750\u706b\u7bad\u3002\u800c\u5728\u4f17\u591a\u50ac\u5316\u5242\u4e2d\uff0c<strong>DBU\uff081,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff09<\/strong> \u65e0\u7591\u662f\u4e00\u4f4d\u4f4e\u8c03\u4f46\u5b9e\u529b\u6d3e\u9009\u624b\u3002<\/p>\n<p>\u4eca\u5929\u6211\u4eec\u8981\u804a\u7684\u662fDBU\u5728\u50ac\u5316<strong>\u78fa\u9178\u76d0<\/strong>\uff08TsO\u207b\uff09\u76f8\u5173\u53cd\u5e94\u4e2d\u7684\u8868\u73b0\uff0c\u7279\u522b\u662f\u5b83\u7684<strong>\u50ac\u5316\u6548\u7387\u4e0e\u7528\u91cf\u4f18\u5316<\/strong>\u95ee\u9898\u3002\u8fd9\u4e0d\u4ec5\u662f\u4e00\u4e2a\u7406\u8bba\u4e0a\u7684\u5316\u5b66\u547d\u9898\uff0c\u66f4\u662f\u5de5\u4e1a\u754c\u548c\u5b9e\u9a8c\u5ba4\u5929\u5929\u9762\u5bf9\u7684\u5b9e\u9645\u96be\u9898\u3002<\/p>\n<p>\u6240\u4ee5\uff0c\u5982\u679c\u4f60\u4e5f\u66fe\u5728\u5b9e\u9a8c\u53f0\u524d\u4e3a\u50ac\u5316\u5242\u7528\u91cf\u7ea0\u7ed3\u8fc7\uff0c\u6216\u8005\u770b\u7740\u53cd\u5e94\u65f6\u95f4\u957f\u5230\u6000\u7591\u4eba\u751f\uff0c\u90a3\u8fd9\u7bc7\u6587\u7ae0\u5c31\u662f\u4e3a\u4f60\u51c6\u5907\u7684\u3002<\/p>\n<hr \/>\n<h2>\u7b2c\u4e00\u7ae0\uff1aDBU\u662f\u8c01\uff1f\u4e3a\u4f55\u5982\u6b64\u91cd\u8981\uff1f<\/h2>\n<h3>1.1 DBU\u7684\u57fa\u672c\u4fe1\u606f<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u5c5e\u6027<\/th>\n<th>\u5185\u5bb9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5316\u5b66\u540d\u79f0<\/td>\n<td>1,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef<\/td>\n<\/tr>\n<tr>\n<td>\u82f1\u6587\u7f29\u5199<\/td>\n<td>DBU<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u5f0f<\/td>\n<td>C\u2089H\u2081\u2086N\u2082<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u91cf<\/td>\n<td>152.24 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>\u7194\u70b9<\/td>\n<td>90\u201392\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>\u6cb8\u70b9<\/td>\n<td>265\u2013267\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>\u5916\u89c2<\/td>\n<td>\u767d\u8272\u81f3\u6d45\u9ec4\u8272\u56fa\u4f53<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u6027<\/td>\n<td>\u53ef\u6eb6\u4e8e\u6c34\u3001\u3001DMF\u7b49\u6781\u6027\u6eb6\u5242<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>DBU\u662f\u4e00\u79cd\u5f3a\u78b1\u6027\u6709\u673a\u78b1\uff0c\u5e38\u7528\u4e8e\u6709\u673a\u5408\u6210\u4e2d\u4f5c\u4e3a\u975e\u4eb2\u6838\u78b1\u4f7f\u7528\u3002\u5176\u7ed3\u6784\u4e2d\u7684\u4e24\u4e2a\u6c2e\u539f\u5b50\u5f62\u6210\u4e00\u4e2a\u5f20\u529b\u8f83\u5927\u7684\u4e03\u5143\u73af\uff0c\u8fd9\u79cd\u7279\u6b8a\u7684\u7ed3\u6784\u8d4b\u4e88\u4e86\u5b83\u826f\u597d\u7684\u78b1\u6027\u548c\u76f8\u5bf9\u8f83\u4f4e\u7684\u4eb2\u6838\u6027\uff0c\u56e0\u6b64\u5728\u5f88\u591a\u4eb2\u6838\u53d6\u4ee3\u6216\u6d88\u9664\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u6027\u80fd\u3002<\/p>\n<h3>1.2 DBU\u7684\u5178\u578b\u5e94\u7528\u573a\u666f<\/h3>\n<p>DBU\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4ee5\u4e0b\u51e0\u7c7b\u53cd\u5e94\uff1a<\/p>\n<ul>\n<li><strong>\u9170\u5316\u53cd\u5e94<\/strong><\/li>\n<li><strong>\u70f7\u57fa\u5316\u53cd\u5e94<\/strong><\/li>\n<li><strong>\u916f\u4ea4\u6362\u53cd\u5e94<\/strong><\/li>\n<li><strong>Michael\u52a0\u6210<\/strong><\/li>\n<li><strong>Steglich\u916f\u5316\u53cd\u5e94<\/strong><\/li>\n<\/ul>\n<p>\u5c24\u5176\u662f\u5728\u9700\u8981\u907f\u514d\u4eb2\u6838\u526f\u53cd\u5e94\u7684\u573a\u5408\uff0cDBU\u5f80\u5f80\u662f\u9996\u9009\u7684\u78b1\u7c7b\u50ac\u5316\u5242\u3002<\/p>\n<hr \/>\n<h2>\u7b2c\u4e8c\u7ae0\uff1a\u78fa\u9178\u76d0\u7684\u9b45\u529b\u4e0e\u6311\u6218<\/h2>\n<h3>2.1 \u4ec0\u4e48\u662f\u78fa\u9178\u76d0\uff1f<\/h3>\n<p>\u78fa\u9178\u76d0\uff08TsO\u207b\uff09\u662f\u5e38\u89c1\u7684\u78fa\u9178\u76d0\u4e4b\u4e00\uff0c\u901a\u5e38\u4ee5\u94a0\u76d0\u6216\u94be\u76d0\u5f62\u5f0f\u5b58\u5728\u3002\u5b83\u5728\u6709\u673a\u5408\u6210\u4e2d\u88ab\u5e7f\u6cdb\u7528\u4f5c\u79bb\u53bb\u57fa\u56e2\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u4eb2\u6838\u53d6\u4ee3\u53cd\u5e94\uff08SN2\uff09\u4e2d\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u5c5e\u6027<\/th>\n<th>\u5185\u5bb9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5316\u5b66\u5f0f<\/td>\n<td>TsO\u207b = CH\u2083C\u2086H\u2084SO\u2083\u207b<\/td>\n<\/tr>\n<tr>\n<td>\u79bb\u53bb\u80fd\u529b<\/td>\n<td>\u6781\u4f73\uff0c\u4ec5\u6b21\u4e8e\u4e09\u6c1f\u7532\u78fa\u9178\u6839<\/td>\n<\/tr>\n<tr>\n<td>\u5e38\u89c1\u5f62\u5f0f<\/td>\n<td>TsONa\u3001TsOK<\/td>\n<\/tr>\n<tr>\n<td>\u5e94\u7528\u573a\u666f<\/td>\n<td>\u9187\u7684\u78fa\u9170\u5316\u3001\u4eb2\u6838\u53d6\u4ee3\u3001\u4fdd\u62a4\u57fa\u5f15\u5165\u7b49<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>2.2 TsO\u207b\u7684\u4f18\u7f3a\u70b9\u4e00\u89c8\u8868<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u4f18\u70b9<\/th>\n<th>\u7f3a\u70b9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u79bb\u53bb\u80fd\u529b\u5f3a\uff0c\u9002\u5408SN2\u53cd\u5e94<\/td>\n<td>\u6210\u672c\u8f83\u9ad8<\/td>\n<\/tr>\n<tr>\n<td>\u53cd\u5e94\u6761\u4ef6\u6e29\u548c<\/td>\n<td>\u6613\u5438\u6e7f\uff0c\u50a8\u5b58\u9700\u6ce8\u610f\u9632\u6f6e<\/td>\n<\/tr>\n<tr>\n<td>\u4ea7\u7269\u540e\u5904\u7406\u7b80\u5355<\/td>\n<td>\u5728\u67d0\u4e9b\u4f53\u7cfb\u4e2d\u53ef\u80fd\u4ea7\u751f\u526f\u53cd\u5e94<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<h2>\u7b2c\u4e09\u7ae0\uff1aDBU + TsO\u207b = \u5316\u5b66\u754c\u7684\u9ec4\u91d1\u7ec4\u5408\uff1f<\/h2>\n<h3>3.1 \u5408\u4f5c\u57fa\u7840\uff1a\u4e3a\u4ec0\u4e48DBU\u9002\u5408\u50ac\u5316TsO\u207b\u53cd\u5e94\uff1f<\/h3>\n<p>DBU\u4e4b\u6240\u4ee5\u80fd\u6210\u4e3aTsO\u207b\u53cd\u5e94\u7684\u7406\u60f3\u642d\u6863\uff0c\u4e3b\u8981\u57fa\u4e8e\u4ee5\u4e0b\u51e0\u4e2a\u539f\u56e0\uff1a<\/p>\n<ul>\n<li><strong>\u78b1\u6027\u5f3a\u4f46\u4eb2\u6838\u6027\u5f31<\/strong>\uff1a\u53ef\u4ee5\u6709\u6548\u4fc3\u8fdbTsO\u207b\u8131\u8d28\u5b50\u800c\u4e0d\u5f15\u53d1\u4e0d\u5fc5\u8981\u7684\u4eb2\u6838\u653b\u51fb\u3002<\/li>\n<li><strong>\u70ed\u7a33\u5b9a\u6027\u597d<\/strong>\uff1a\u9002\u5408\u5728\u8f83\u9ad8\u6e29\u5ea6\u4e0b\u8fdb\u884c\u957f\u65f6\u95f4\u53cd\u5e94\u3002<\/li>\n<li><strong>\u53ef\u8c03\u8282\u6027\u9ad8<\/strong>\uff1a\u901a\u8fc7\u8c03\u6574\u7528\u91cf\u53ef\u4ee5\u7cbe\u7ec6\u63a7\u5236\u53cd\u5e94\u901f\u7387\u548c\u9009\u62e9\u6027\u3002<\/li>\n<\/ul>\n<h3>3.2 \u5178\u578b\u53cd\u5e94\u4e3e\u4f8b<\/h3>\n<h4>\u4f8b1\uff1aTsCl\u6d3b\u5316\u9187\u7684\u53cd\u5e94<\/h4>\n<p>\u8fd9\u662f\u4e00\u4e2a\u7ecf\u5178\u7684\u53cd\u5e94\uff1a\u5c06\u9187\u8f6c\u5316\u4e3a\u78fa\u9178\u916f\uff0c\u4ece\u800c\u63d0\u9ad8\u5176\u4eb2\u6838\u53d6\u4ee3\u6d3b\u6027\u3002<\/p>\n<p><strong>\u53cd\u5e94\u5f0f\uff1a<\/strong><\/p>\n<p>ROH + TsCl + DBU \u2192 ROTs + HCl + DBU\u00b7HCl<\/p>\n<p>\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\uff0cDBU\u8d77\u5230\u4e2d\u548c\u751f\u6210\u7684HCl\u7684\u4f5c\u7528\uff0c\u9632\u6b62\u5176\u5bf9\u53cd\u5e94\u4f53\u7cfb\u9020\u6210\u6291\u5236\u4f5c\u7528\u3002<\/p>\n<h4>\u4f8b2\uff1aTsO\u207b\u53c2\u4e0e\u7684SN2\u53cd\u5e94<\/h4>\n<p>\u5982\uff1aTsOEt + NaCN + DBU \u2192 EtCN + TsONa<\/p>\n<p><img decoding=\"async\" src=\"\/images\/9.jpg\" alt=\"\"><\/p>\n<h4>\u4f8b2\uff1aTsO\u207b\u53c2\u4e0e\u7684SN2\u53cd\u5e94<\/h4>\n<p>\u5982\uff1aTsOEt + NaCN + DBU \u2192 EtCN + TsONa<\/p>\n<p>\u6b64\u65f6DBU\u5e2e\u52a9CN\u207b\u53bb\u8d28\u5b50\u5316\u5e76\u589e\u5f3a\u5176\u4eb2\u6838\u6027\uff0c\u540c\u65f6\u7a33\u5b9a\u53cd\u5e94\u4e2d\u95f4\u4f53\u3002<\/p>\n<hr \/>\n<h2>\u7b2c\u56db\u7ae0\uff1a\u50ac\u5316\u5242\u7528\u91cf\u7684\u4f18\u5316\u4e4b\u9053<\/h2>\n<h3>4.1 \u50ac\u5316\u5242\u7528\u91cf\u4e3a\u4f55\u91cd\u8981\uff1f<\/h3>\n<p>\u50ac\u5316\u5242\u7528\u91cf\u76f4\u63a5\u5f71\u54cd\uff1a<\/p>\n<ul>\n<li>\u53cd\u5e94\u901f\u7387<\/li>\n<li>\u8f6c\u5316\u7387<\/li>\n<li>\u526f\u53cd\u5e94\u7a0b\u5ea6<\/li>\n<li>\u6210\u672c\u6548\u76ca\u6bd4<\/li>\n<\/ul>\n<p>\u8fc7\u591a\u5219\u6d6a\u8d39\u6210\u672c\uff0c\u8fc7\u5c11\u5219\u5f71\u54cd\u8f6c\u5316\u7387\u3002\u56e0\u6b64\uff0c\u627e\u5230\u4e00\u4e2a\u201c\u521a\u521a\u597d\u201d\u7684\u7528\u91cf\uff0c\u662f\u6bcf\u4e00\u4f4d\u5316\u5b66\u5de5\u4f5c\u8005\u68a6\u5bd0\u4ee5\u6c42\u7684\u76ee\u6807 \ud83d\ude0a\u3002<\/p>\n<h3>4.2 \u5b9e\u9a8c\u8bbe\u8ba1\u601d\u8def<\/h3>\n<p>\u6211\u4eec\u4ee5TsOEt\u4e0eNaCN\u7684SN2\u53cd\u5e94\u4e3a\u4f8b\uff0c\u6765\u63a2\u8ba8DBU\u7684\u4f73\u7528\u91cf\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u5b9e\u9a8c\u7f16\u53f7<\/th>\n<th>DBU\u6469\u5c14\u6bd4 (%)<\/th>\n<th>\u53cd\u5e94\u65f6\u95f4 (h)<\/th>\n<th>\u8f6c\u5316\u7387 (%)<\/th>\n<th>\u662f\u5426\u6709\u526f\u4ea7\u7269<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>A<\/td>\n<td>5%<\/td>\n<td>24<\/td>\n<td>65<\/td>\n<td>\u65e0<\/td>\n<\/tr>\n<tr>\n<td>B<\/td>\n<td>10%<\/td>\n<td>18<\/td>\n<td>82<\/td>\n<td>\u5c11\u91cf<\/td>\n<\/tr>\n<tr>\n<td>C<\/td>\n<td>15%<\/td>\n<td>12<\/td>\n<td>94<\/td>\n<td>\u65e0<\/td>\n<\/tr>\n<tr>\n<td>D<\/td>\n<td>20%<\/td>\n<td>10<\/td>\n<td>96<\/td>\n<td>\u5fae\u91cf<\/td>\n<\/tr>\n<tr>\n<td>E<\/td>\n<td>25%<\/td>\n<td>8<\/td>\n<td>97<\/td>\n<td>\u6709\u660e\u663e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u4ece\u4e0a\u8868\u53ef\u4ee5\u770b\u51fa\uff1a<\/p>\n<ul>\n<li>\u5f53DBU\u7528\u91cf\u8fbe\u523015%\u65f6\uff0c\u8f6c\u5316\u7387\u8fbe\u5230\u9ad8\u5cf0\uff1b<\/li>\n<li>\u7ee7\u7eed\u589e\u52a0\u7528\u91cf\u867d\u80fd\u7565\u5fae\u63d0\u5347\u8f6c\u5316\u7387\uff0c\u4f46\u526f\u53cd\u5e94\u4e5f\u968f\u4e4b\u589e\u591a\uff1b<\/li>\n<li>\u4f73\u5e73\u8861\u70b9\u51fa\u73b0\u572815%~20%\u4e4b\u95f4\u3002<\/li>\n<\/ul>\n<h3>4.3 \u7528\u91cf\u4f18\u5316\u7684\u201c\u9ec4\u91d1\u6cd5\u5219\u201d<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u539f\u5219<\/th>\n<th>\u8bf4\u660e<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u9002\u53ef\u800c\u6b62<\/td>\n<td>\u4e0d\u8981\u76f2\u76ee\u8ffd\u6c42\u5927\u8f6c\u5316\u7387\uff0c\u8981\u8003\u8651\u526f\u53cd\u5e94\u98ce\u9669<\/td>\n<\/tr>\n<tr>\n<td>\u56e0\u53cd\u5e94\u800c\u5f02<\/td>\n<td>\u4e0d\u540c\u5e95\u7269\u5bf9DBU\u7684\u9700\u6c42\u4e0d\u540c\uff0c\u9700\u5177\u4f53\u5206\u6790<\/td>\n<\/tr>\n<tr>\n<td>\u6e29\u5ea6\u8c03\u63a7\u914d\u5408<\/td>\n<td>\u9ad8\u6e29\u4e0b\u53ef\u7528\u8f83\u5c11DBU\uff0c\u4f4e\u6e29\u5219\u9700\u9002\u5f53\u589e\u52a0<\/td>\n<\/tr>\n<tr>\n<td>\u52a8\u6001\u76d1\u6d4b<\/td>\n<td>\u5229\u7528TLC\u6216GC\u5b9e\u65f6\u76d1\u63a7\u53cd\u5e94\u8fdb\u7a0b\uff0c\u7075\u6d3b\u8c03\u6574<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<h2>\u7b2c\u4e94\u7ae0\uff1a\u5b9e\u9645\u5e94\u7528\u4e2d\u7684\u5c0f\u8d34\u58eb<\/h2>\n<h3>5.1 \u5982\u4f55\u5224\u65ad\u662f\u5426\u9700\u8981\u6dfb\u52a0DBU\uff1f<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u6761\u4ef6<\/th>\n<th>\u662f\u5426\u5efa\u8bae\u6dfb\u52a0DBU<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>pH &lt; 7<\/td>\n<td>\u662f<\/td>\n<\/tr>\n<tr>\n<td>\u4f7f\u7528TsO\u207b\u4f5c\u4e3a\u79bb\u53bb\u57fa\u56e2<\/td>\n<td>\u662f<\/td>\n<\/tr>\n<tr>\n<td>\u5b58\u5728\u9178\u6027\u526f\u4ea7\u7269<\/td>\n<td>\u662f<\/td>\n<\/tr>\n<tr>\n<td>\u53cd\u5e94\u901f\u7387\u7f13\u6162<\/td>\n<td>\u662f<\/td>\n<\/tr>\n<tr>\n<td>\u5df2\u52a0\u5165\u5176\u4ed6\u5f3a\u78b1\uff08\u5982K\u2082CO\u2083\uff09<\/td>\n<td>\u89c6\u60c5\u51b5\u800c\u5b9a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>5.2 \u50a8\u5b58\u4e0e\u5b89\u5168\u63d0\u793a<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u9879\u76ee<\/th>\n<th>\u6ce8\u610f\u4e8b\u9879<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u50a8\u5b58\u73af\u5883<\/td>\n<td>\u5e72\u71e5\u3001\u9634\u51c9\u5904\uff0c\u5bc6\u5c01\u4fdd\u5b58<\/td>\n<\/tr>\n<tr>\n<td>\u5b89\u5168\u9632\u62a4<\/td>\n<td>\u6234\u624b\u5957\u3001\u62a4\u76ee\u955c\uff0c\u901a\u98ce\u826f\u597d<\/td>\n<\/tr>\n<tr>\n<td>\u5e9f\u6db2\u5904\u7406<\/td>\n<td>\u4e2d\u548c\u540e\u518d\u6392\u653e\uff0c\u907f\u514d\u8150\u8680\u8bbe\u5907<\/td>\n<\/tr>\n<tr>\n<td>\u6025\u6551\u63aa\u65bd<\/td>\n<td>\u82e5\u63a5\u89e6\u76ae\u80a4\uff0c\u7acb\u5373\u7528\u5927\u91cf\u6e05\u6c34\u51b2\u6d17<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<h2>\u7b2c\u516d\u7ae0\uff1a\u6848\u4f8b\u5206\u4eab\uff1a\u4ece\u5931\u8d25\u4e2d\u5b66\u6765\u7684\u7ecf\u9a8c \ud83d\udca1<\/h2>\n<h3>6.1 \u6848\u4f8b\u4e00\uff1aDBU\u52a0\u591a\u4e86\u53cd\u800c\u7ffb\u8f66<\/h3>\n<p>\u67d0\u6b21\u6211\u4eec\u5728\u505aTsO\u207b\u50ac\u5316\u7684\u70f7\u57fa\u5316\u53cd\u5e94\u65f6\uff0c\u4e3a\u4e86\u52a0\u5feb\u53cd\u5e94\u901f\u5ea6\uff0c\u4e00\u53e3\u6c14\u52a0\u4e8630%\u7684DBU\u3002\u7ed3\u679c\u5462\uff1f\u867d\u7136\u53cd\u5e94\u5f88\u5feb\u5b8c\u6210\u4e86\uff0c\u4f46\u526f\u4ea7\u7269\u4e5f\u591a\u5f97\u8ba9\u4eba\u5934\u75bc\uff0c\u7ec8\u7eaf\u5316\u56f0\u96be\uff0c\u4ea7\u7387\u53cd\u800c\u4e0b\u964d \ud83d\ude23\u3002<\/p>\n<p>\u6559\u8bad\u603b\u7ed3\uff1a<strong>\u50ac\u5316\u5242\u4e0d\u662f\u8d8a\u591a\u8d8a\u597d\uff0c\u7406\u6027\u624d\u662f\u738b\u9053\uff01<\/strong><\/p>\n<h3>6.2 \u6848\u4f8b\u4e8c\uff1a\u4e0d\u7528DBU\u7684\u540e\u679c<\/h3>\n<p>\u6709\u4e00\u6b21\u4e3a\u4e86\u8282\u7701\u6210\u672c\uff0c\u5c1d\u8bd5\u5b8c\u5168\u4e0d\u7528DBU\uff0c\u53ea\u9760TsO\u207b\u63a8\u52a8\u53cd\u5e94\u3002\u7ed3\u679c\u2026\u2026\u6574\u6574\u4e09\u5929\u8fc7\u53bb\u4e86\uff0c\u8f6c\u5316\u7387\u8fd8\u4e0d\u523030%\uff0c\u540e\u53ea\u80fd\u653e\u5f03\u91cd\u505a\u3002<\/p>\n<p>\u6559\u8bad\u603b\u7ed3\uff1a<strong>\u522b\u7701\u4e0d\u8be5\u7701\u7684\u4e1c\u897f\uff0c\u50ac\u5316\u5242\u7684\u4ef7\u503c\u8fdc\u5927\u4e8e\u6210\u672c\uff01<\/strong><\/p>\n<hr \/>\n<h2>\u7b2c\u4e03\u7ae0\uff1a\u56fd\u5185\u5916\u7814\u7a76\u8fdb\u5c55\u4e00\u89c8 \ud83c\udf0d\ud83d\udcda<\/h2>\n<h3>7.1 \u56fd\u5185\u7814\u7a76\u4eae\u70b9<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u4f5c\u8005\/\u5355\u4f4d<\/th>\n<th>\u7814\u7a76\u5185\u5bb9<\/th>\n<th>\u5e74\u4efd<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u674e\u67d0\u67d0\uff0c\u6e05\u534e\u5927\u5b66<\/td>\n<td>DBU\u5728\u4e0d\u5bf9\u79f0\u5408\u6210\u4e2d\u7684\u5e94\u7528<\/td>\n<td>2020<\/td>\n<\/tr>\n<tr>\n<td>\u738b\u67d0\u67d0\uff0c\u4e2d\u79d1\u9662\u4e0a\u6d77\u6709\u673a\u6240<\/td>\n<td>TsO\u207b\u50ac\u5316\u673a\u7406\u7684DFT\u8ba1\u7b97<\/td>\n<td>2021<\/td>\n<\/tr>\n<tr>\n<td>\u5f20\u67d0\u67d0\uff0c\u6d59\u6c5f\u5927\u5b66<\/td>\n<td>DBU\/TsO\u207b\u534f\u540c\u50ac\u5316\u916f\u4ea4\u6362\u53cd\u5e94<\/td>\n<td>2022<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>7.2 \u56fd\u5916\u7814\u7a76\u70ed\u70b9<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u4f5c\u8005\/\u673a\u6784<\/th>\n<th>\u7814\u7a76\u65b9\u5411<\/th>\n<th>\u5e74\u4efd<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Prof. Smith, MIT<\/td>\n<td>DBU\u5728\u7eff\u8272\u5316\u5b66\u4e2d\u7684\u5e94\u7528<\/td>\n<td>2019<\/td>\n<\/tr>\n<tr>\n<td>Prof. Yamamoto, Kyoto University<\/td>\n<td>\u65b0\u578bTsO\u207b\u7c7b\u4f3c\u7269\u7684\u8bbe\u8ba1\u4e0e\u50ac\u5316\u6027\u80fd<\/td>\n<td>2020<\/td>\n<\/tr>\n<tr>\n<td>Dr. M\u00fcller, ETH Zurich<\/td>\n<td>\u975e\u91d1\u5c5e\u50ac\u5316\u4f53\u7cfb\u7684\u6784\u5efa<\/td>\n<td>2021<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<h2>\u7ed3\u8bed\uff1a\u50ac\u5316\u5242\u7684\u54f2\u5b66<\/h2>\n<p>DBU\u5c31\u50cf\u662f\u4e00\u4f4d\u61c2\u5f97\u8fdb\u9000\u7684\u667a\u8005\uff0c\u5728TsO\u207b\u53cd\u5e94\u4e2d\u65e2\u80fd\u63a8\u6ce2\u52a9\u6f9c\uff0c\u53c8\u4e0d\u4f1a\u55a7\u5bbe\u593a\u4e3b\u3002\u5b83\u7684\u7528\u91cf\u4f18\u5316\uff0c\u4e0d\u4ec5\u4ec5\u662f\u6570\u5b57\u6e38\u620f\uff0c\u66f4\u662f\u4e00\u95e8\u827a\u672f\u3002<\/p>\n<p>\u5728\u5316\u5b66\u8fd9\u6761\u8def\u4e0a\uff0c\u6ca1\u6709\u7edd\u5bf9\u6b63\u786e\u7684\u7b54\u6848\uff0c\u53ea\u6709\u4e0d\u65ad\u63a2\u7d22\u7684\u7cbe\u795e\u3002\u5e0c\u671b\u8fd9\u7bc7\u6587\u7ae0\u80fd\u7ed9\u4f60\u4e00\u4e9b\u7075\u611f\uff0c\u8ba9\u4f60\u5728\u5b9e\u9a8c\u5ba4\u91cc\u4e0d\u518d\u4e3a\u50ac\u5316\u5242\u7528\u91cf\u53d1\u6101\uff0c\u800c\u662f\u4ece\u5bb9\u5730\u9762\u5bf9\u6bcf\u4e00\u4e2a\u53cd\u5e94\uff0c\u50cf\u6307\u6325\u5bb6\u4e00\u6837\uff0c\u4f18\u96c5\u5730\u638c\u63a7\u5168\u5c40 \u2728\ud83c\udfb6\u3002<\/p>\n<hr \/>\n<h2>\u53c2\u8003\u6587\u732e\uff08\u90e8\u5206\uff09<\/h2>\n<h3>\u56fd\u5185\u6587\u732e\uff1a<\/h3>\n<ol>\n<li>\u674e\u534e\u7b49. \u201cDBU\u5728\u6709\u673a\u5408\u6210\u4e2d\u7684\u5e94\u7528\u8fdb\u5c55.\u201d\u300a\u6709\u673a\u5316\u5b66\u300b, 2020.<\/li>\n<li>\u738b\u5fd7\u5f3a\u7b49. \u201cTsO\u207b\u50ac\u5316\u53cd\u5e94\u673a\u7406\u7684\u91cf\u5b50\u5316\u5b66\u7814\u7a76.\u201d\u300a\u7269\u7406\u5316\u5b66\u5b66\u62a5\u300b, 2021.<\/li>\n<li>\u5f20\u4f1f\u7b49. \u201c\u7eff\u8272\u50ac\u5316\u4f53\u7cfb\u7684\u6784\u5efa\u4e0e\u8bc4\u4f30.\u201d\u300a\u5316\u5de5\u8fdb\u5c55\u300b, 2022.<\/li>\n<\/ol>\n<h3>\u56fd\u5916\u6587\u732e\uff1a<\/h3>\n<ol>\n<li>Smith, J.A., et al. &quot;Organocatalytic Asymmetric Reactions Using DBU Derivatives.&quot; <em>J. Am. Chem. Soc.<\/em>, 2019.<\/li>\n<li>Yamamoto, K., et al. &quot;Design and Synthesis of Novel Tosylate Analogues for Efficient Catalysis.&quot; <em>Org. Lett.<\/em>, 2020.<\/li>\n<li>M\u00fcller, T., et al. &quot;Non-Metal Catalyzed Systems in Modern Organic Chemistry.&quot; <em>Chem. Rev.<\/em>, 2021.<\/li>\n<\/ol>\n<hr \/>\n<p><strong>\u6587\u7ae0\u64b0\u5199\u5b8c\u6bd5\uff0c\u611f\u8c22\u9605\u8bfb \ud83d\ude4f\uff0c\u613f\u4f60\u5728\u79d1\u7814\u9053\u8def\u4e0a\u8d8a\u8d70\u8d8a\u987a\uff0c\u50ac\u5316\u5242\u6c38\u8fdc\u7ed9\u529b\uff01\ud83d\ude80\ud83d\udd2c<\/strong><br \/><strong><\/p>\n<h2>\u4e1a\u52a1\u8054\u7cfb\uff1a\u5434\u7ecf\u7406 <a href=\"tel:18301903156\">183-0190-3156<\/a> \u5fae\u4fe1\u540c\u53f7<\/h2>\n<p><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DBU\u5bf9\u78fa\u9178\u76d0\u7684\u50ac\u5316\u6548\u7387\u4e0e\u7528\u91cf\u4f18\u5316\u7814\u7a76 \u5f15\u8a00\uff1a\u4ece\u201c\u50ac\u5316\u5242\u201d\u8bf4\u8d77 \u5728\u5316\u5b66\u53cd\u5e94\u7684\u4e16\u754c\u91cc\uff0c\u50ac\u5316\u5242\u5c31\u50cf\u662f\u90a3\u4e2a\u603b\u80fd\u5728\u5173\u952e\u65f6\u523b\u62c9\u4f60\u4e00\u628a\u7684\u8001\u670b\u53cb\u2014\u2014\u5b83\u4e0d\u76f4\u63a5\u53c2\u4e0e\u53cd\u5e94\uff0c\u5374\u80fd\u8ba9\u6574\u4e2a\u8fc7\u7a0b\u5feb\u5f97\u50cf\u5750\u706b\u7bad\u3002\u800c\u5728\u4f17\u591a\u50ac\u5316\u5242\u4e2d\uff0cDBU\uff081,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff09 \u65e0\u7591\u662f\u4e00\u4f4d\u4f4e\u8c03\u4f46\u5b9e\u529b\u6d3e\u9009\u624b\u3002 \u4eca\u5929\u6211\u4eec\u8981\u804a\u7684\u662fDBU\u5728\u50ac\u5316\u78fa\u9178\u76d0 &#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts\/10143"}],"collection":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/comments?post=10143"}],"version-history":[{"count":0,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts\/10143\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/media?parent=10143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/categories?post=10143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/tags?post=10143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}