{"id":10187,"date":"2025-06-12T22:29:51","date_gmt":"2025-06-12T14:29:51","guid":{"rendered":"https:\/\/www.shorro.cn\/index.php\/archives\/10187"},"modified":"2025-06-12T22:29:51","modified_gmt":"2025-06-12T14:29:51","slug":"%e6%af%94%e8%be%83dbu%e7%94%b2%e9%85%b8%e7%9b%90%e4%b8%8e%e5%85%b6%e4%bb%96%e8%83%ba%e7%b1%bb%e5%82%ac%e5%8c%96%e5%89%82%e7%9a%84%e6%80%a7%e8%83%bd%e5%b7%ae%e5%bc%82","status":"publish","type":"post","link":"https:\/\/www.shorro.cn\/index.php\/archives\/10187","title":{"rendered":"\u6bd4\u8f83DBU\u7532\u9178\u76d0\u4e0e\u5176\u4ed6\u80fa\u7c7b\u50ac\u5316\u5242\u7684\u6027\u80fd\u5dee\u5f02"},"content":{"rendered":"<h1>DBU\u7532\u9178\u76d0\u4e0e\u5176\u4ed6\u80fa\u7c7b\u50ac\u5316\u5242\u7684\u6027\u80fd\u5dee\u5f02\u6bd4\u8f83<\/h1>\n<h2>\u5f15\u8a00\uff1a\u5316\u5b66\u53cd\u5e94\u4e2d\u7684\u201c\u5e55\u540e\u82f1\u96c4\u201d<\/h2>\n<p>\u5728\u5316\u5b66\u5408\u6210\u7684\u4e16\u754c\u91cc\uff0c\u50ac\u5316\u5242\u5c31\u50cf\u662f\u4e00\u7fa4\u9ed8\u9ed8\u65e0\u95fb\u7684\u201c\u5e55\u540e\u82f1\u96c4\u201d\u3002\u5b83\u4eec\u4e0d\u76f4\u63a5\u53c2\u4e0e\u7ec8\u4ea7\u7269\u7684\u751f\u6210\uff0c\u5374\u80fd\u5927\u5927\u63d0\u5347\u53cd\u5e94\u6548\u7387\u3001\u964d\u4f4e\u80fd\u8017\u3001\u7f29\u77ed\u53cd\u5e94\u65f6\u95f4\u3002\u800c\u5728\u4f17\u591a\u50ac\u5316\u5242\u4e2d\uff0c<strong>DBU\uff081,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff09\u7532\u9178\u76d0<\/strong>\u4f5c\u4e3a\u4e00\u79cd\u975e\u5bf9\u79f0\u5f3a\u78b1\u6027\u6709\u673a\u78b1\u50ac\u5316\u5242\uff0c\u5728\u8fd1\u5e74\u6765\u53d7\u5230\u4e86\u8d8a\u6765\u8d8a\u591a\u7684\u5173\u6ce8\u3002<\/p>\n<p>\u4f46\u8bdd\u8bf4\u56de\u6765\uff0cDBU\u7532\u9178\u76d0\u771f\u7684\u5c31\u6bd4\u5176\u4ed6\u80fa\u7c7b\u50ac\u5316\u5242\u66f4\u80dc\u4e00\u7b79\u5417\uff1f\u5b83\u5230\u5e95\u6709\u4ec0\u4e48\u7279\u522b\u4e4b\u5904\uff1f\u6211\u4eec\u4eca\u5929\u5c31\u6765\u63b0\u626f\u63b0\u626f\u2014\u2014\u4ece\u5b83\u7684\u7ed3\u6784\u7279\u6027\u3001\u50ac\u5316\u673a\u7406\u3001\u9002\u7528\u8303\u56f4\uff0c\u518d\u5230\u4e0e\u4e09\u4e59\u80fa\u3001DMAP\u3001TEA\u7b49\u5e38\u89c1\u80fa\u7c7b\u50ac\u5316\u5242\u7684\u5bf9\u6bd4\u5206\u6790\uff0c\u5e26\u4f60\u5168\u65b9\u4f4d\u4e86\u89e3\u8fd9\u4f4d\u201c\u5316\u5b66\u754c\u7684\u65b0\u664b\u7f51\u7ea2\u201d\u3002<\/p>\n<hr \/>\n<h2>\u4e00\u3001\u4ec0\u4e48\u662fDBU\u7532\u9178\u76d0\uff1f<\/h2>\n<h3>1.1 \u5316\u5b66\u7ed3\u6784\u7b80\u8ff0<\/h3>\n<p>DBU\u7684\u5168\u540d\u662f1,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff0c\u662f\u4e00\u79cd\u5177\u6709\u9ad8\u5ea6\u7a7a\u95f4\u4f4d\u963b\u7684\u975e\u5bf9\u79f0\u5f3a\u78b1\u6027\u6709\u673a\u78b1\u3002\u5176\u7ed3\u6784\u5982\u4e0b\u56fe\u6240\u793a\uff1a<\/p>\n<pre><code>        N\n       \/ \n      C   C\n     \/  \/ \n    C   C   C\n   \/  \/  \/ \n  C   C   C   C\n    \/  \/  \/\n    C   C   C\n      \/  \/\n      C   C\n        \/\n        N<\/code><\/pre>\n<p>\u800cDBU\u7532\u9178\u76d0\u5219\u662fDBU\u4e0e\u7532\u9178\u5f62\u6210\u7684\u76d0\u7c7b\u5316\u5408\u7269\uff0c\u901a\u5e38\u4ee5\u767d\u8272\u56fa\u4f53\u5f62\u5f0f\u5b58\u5728\uff0c\u6613\u6eb6\u4e8e\u6781\u6027\u6eb6\u5242\u5982\u3001\u548c\u6c34\u3002\u7531\u4e8e\u5176\u72ec\u7279\u7684\u7ed3\u6784\uff0cDBU\u7532\u9178\u76d0\u4e0d\u4ec5\u5177\u5907\u5f3a\u78b1\u6027\uff0c\u8fd8\u5177\u6709\u826f\u597d\u7684\u4eb2\u6838\u6027\u548c\u7a33\u5b9a\u6027\u3002<\/p>\n<h3>1.2 \u57fa\u672c\u7269\u7406\u5316\u5b66\u53c2\u6570<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u53c2\u6570<\/th>\n<th>\u6570\u503c<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5206\u5b50\u5f0f<\/td>\n<td>C\u2081\u2081H\u2082\u2080N\u2082O\u2082<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u91cf<\/td>\n<td>212.29 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>\u7194\u70b9<\/td>\n<td>168\u2013170\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>\u6cb8\u70b9<\/td>\n<td>\u4e0d\u9002\u7528\uff08\u5206\u89e3\uff09<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u6027<\/td>\n<td>\u53ef\u6eb6\u4e8e\u6c34\u3001\u3001DMF\u3001DMSO<\/td>\n<\/tr>\n<tr>\n<td>pKa<\/td>\n<td>~13.5\uff08\u5728\u6c34\u4e2d\uff09<\/td>\n<\/tr>\n<tr>\n<td>\u78b1\u6027\u5f3a\u5f31<\/td>\n<td>\u5f3a\u78b1\u6027\uff08&gt;DBN &gt; DABCO\uff09<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<h2>\u4e8c\u3001\u5e38\u89c1\u7684\u80fa\u7c7b\u50ac\u5316\u5242\u6709\u54ea\u4e9b\uff1f<\/h2>\n<p>\u5728\u6709\u673a\u5408\u6210\u4e2d\uff0c\u5e38\u7528\u7684\u80fa\u7c7b\u50ac\u5316\u5242\u79cd\u7c7b\u7e41\u591a\uff0c\u6bcf\u79cd\u90fd\u6709\u5176\u7279\u5b9a\u7684\u5e94\u7528\u573a\u666f\u548c\u4f18\u52bf\u3002\u4ee5\u4e0b\u662f\u51e0\u79cd\u5e38\u89c1\u7684\u80fa\u7c7b\u50ac\u5316\u5242\u53ca\u5176\u7279\u70b9\uff1a<\/p>\n<h3>2.1 \u4e09\u4e59\u80fa\uff08Triethylamine, TEA\uff09<\/h3>\n<ul>\n<li><strong>\u5206\u5b50\u5f0f<\/strong>\uff1aC\u2086H\u2081\u2085N  <\/li>\n<li><strong>pKa<\/strong>\uff1a~10.7  <\/li>\n<li><strong>\u7528\u9014<\/strong>\uff1a\u5e38\u7528\u4e8e\u916f\u5316\u3001\u9170\u5316\u3001\u70f7\u57fa\u5316\u7b49\u53cd\u5e94  <\/li>\n<li><strong>\u4f18\u70b9<\/strong>\uff1a\u4ef7\u683c\u4fbf\u5b9c\u3001\u4f7f\u7528\u65b9\u4fbf  <\/li>\n<li><strong>\u7f3a\u70b9<\/strong>\uff1a\u78b1\u6027\u8f83\u5f31\u3001\u5bb9\u6613\u6325\u53d1\u3001\u6c14\u5473\u523a\u9f3b  <\/li>\n<\/ul>\n<h3>2.2 DMAP\uff084-\u4e8c\u7532\u6c28\u57fa\u5421\u5576\uff09<\/h3>\n<ul>\n<li><strong>\u5206\u5b50\u5f0f<\/strong>\uff1aC\u2087H\u2081\u2080N\u2082  <\/li>\n<li><strong>pKa<\/strong>\uff1a~9.7  <\/li>\n<li><strong>\u7528\u9014<\/strong>\uff1a\u4e3b\u8981\u7528\u4e8e\u916f\u5316\u3001\u9170\u5316\u53cd\u5e94\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u6d3b\u6027\u8f83\u4f4e\u7684\u5e95\u7269  <\/li>\n<li><strong>\u4f18\u70b9<\/strong>\uff1a\u9ad8\u6548\u3001\u9009\u62e9\u6027\u597d  <\/li>\n<li><strong>\u7f3a\u70b9<\/strong>\uff1a\u4ef7\u683c\u8f83\u9ad8\u3001\u9700\u6ce8\u610f\u6bd2\u6027\u95ee\u9898  <\/li>\n<\/ul>\n<h3>2.3 DBU\u672c\u8eab\uff08\u672a\u6210\u76d0\u72b6\u6001\uff09<\/h3>\n<ul>\n<li><strong>pKa<\/strong>\uff1a~13.5  <\/li>\n<li><strong>\u7528\u9014<\/strong>\uff1a\u5f3a\u78b1\u6027\u6761\u4ef6\u4e0b\u7684\u7f29\u5408\u3001Michael\u52a0\u6210\u3001Baylis-Hillman\u53cd\u5e94\u7b49  <\/li>\n<li><strong>\u4f18\u70b9<\/strong>\uff1a\u78b1\u6027\u5f3a\u3001\u53ef\u4f5c\u4e3a\u6c22\u53d7\u4f53  <\/li>\n<li><strong>\u7f3a\u70b9<\/strong>\uff1a\u4e0d\u6613\u56de\u6536\u3001\u4ef7\u683c\u7565\u9ad8  <\/li>\n<\/ul>\n<h3>2.4 \u5176\u4ed6\u5e38\u7528\u80fa\u7c7b\u50ac\u5316\u5242\u7b80\u8868<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u5206\u5b50\u5f0f<\/th>\n<th>pKa<\/th>\n<th>\u4e3b\u8981\u7528\u9014<\/th>\n<th>\u7279\u70b9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5421\u5576<\/td>\n<td>C\u2085H\u2085N<\/td>\n<td>~5.6<\/td>\n<td>\u9170\u5316\u3001\u6c27\u5316<\/td>\n<td>\u78b1\u6027\u5f31\uff0c\u5e7f\u6cdb\u4f7f\u7528<\/td>\n<\/tr>\n<tr>\n<td>DIPEA\uff08N,N-\u4e8c\u5f02\u4e19\u57fa\u4e59\u80fa\uff09<\/td>\n<td>C\u2088H\u2081\u2089N<\/td>\n<td>~11.2<\/td>\n<td>\u591a\u80bd\u5408\u6210\u3001\u5076\u8054\u53cd\u5e94<\/td>\n<td>\u7a7a\u95f4\u4f4d\u963b\u5927\uff0c\u9002\u5408\u590d\u6742\u4f53\u7cfb<\/td>\n<\/tr>\n<tr>\n<td>LDA\uff08\u4e8c\u5f02\u4e19\u57fa\u6c28\u57fa\u9502\uff09<\/td>\n<td>LiN(i-C\u2083H\u2087)\u2082<\/td>\n<td>~35\uff08\u8d85\u5f3a\u78b1\uff09<\/td>\n<td>\u8131\u8d28\u5b50\u53cd\u5e94<\/td>\n<td>\u9700\u4f4e\u6e29\u64cd\u4f5c\uff0c\u5371\u9669\u6027\u9ad8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<h2>\u4e09\u3001DBU\u7532\u9178\u76d0\u7684\u72ec\u7279\u9b45\u529b<\/h2>\n<h3>3.1 \u7ed3\u6784\u51b3\u5b9a\u529f\u80fd\uff1a\u4e3a\u4ec0\u4e48\u9009\u62e9DBU\u7532\u9178\u76d0\uff1f<\/h3>\n<p>DBU\u672c\u8eab\u5c31\u662f\u4e00\u4e2a\u975e\u5e38\u4f18\u79c0\u7684\u78b1\u6027\u50ac\u5316\u5242\uff0c\u4f46\u5f53\u5b83\u4e0e\u7532\u9178\u5f62\u6210\u76d0\u4e4b\u540e\uff0c\u6027\u8d28\u53d1\u751f\u4e86\u4e00\u4e9b\u5fae\u5999\u7684\u53d8\u5316\uff1a<\/p>\n<ul>\n<li><strong>\u7a33\u5b9a\u6027\u589e\u5f3a<\/strong>\uff1a\u76f8\u6bd4\u6e38\u79bbDBU\uff0c\u7532\u9178\u76d0\u5f62\u5f0f\u66f4\u7a33\u5b9a\uff0c\u4fbf\u4e8e\u50a8\u5b58\u548c\u8fd0\u8f93\uff1b<\/li>\n<li><strong>\u6eb6\u89e3\u6027\u66f4\u597d<\/strong>\uff1a\u5728\u6781\u6027\u6eb6\u5242\u4e2d\u6eb6\u89e3\u5ea6\u66f4\u9ad8\uff0c\u5c24\u5176\u9002\u5408\u6c34\u76f8\u6216\u6df7\u5408\u6eb6\u5242\u4f53\u7cfb\uff1b<\/li>\n<li><strong>\u8c03\u63a7\u78b1\u6027\u5f3a\u5ea6<\/strong>\uff1a\u901a\u8fc7\u8c03\u8282\u76d0\u7684\u5f62\u5f0f\uff0c\u53ef\u4ee5\u5fae\u8c03\u5176\u78b1\u6027\u5f3a\u5ea6\uff0c\u9002\u5e94\u4e0d\u540c\u53cd\u5e94\u9700\u6c42\uff1b<\/li>\n<li><strong>\u526f\u4ea7\u7269\u53ef\u63a7<\/strong>\uff1a\u7532\u9178\u4f5c\u4e3a\u5f31\u9178\uff0c\u91ca\u653e\u540e\u4e0d\u4f1a\u5f15\u5165\u5f3a\u9178\u6027\u73af\u5883\uff0c\u6709\u5229\u4e8e\u540e\u7eed\u5206\u79bb\u63d0\u7eaf\u3002<\/li>\n<\/ul>\n<h3>3.2 \u5e94\u7528\u9886\u57df\u4e00\u89c8<\/h3>\n<p>DBU\u7532\u9178\u76d0\u5728\u4ee5\u4e0b\u51e0\u7c7b\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u8272\uff1a<\/p>\n<ul>\n<li><strong>\u916f\u5316\u53cd\u5e94<\/strong>\uff1a\u4fc3\u8fdb\u7fa7\u9178\u4e0e\u9187\u7684\u7f29\u5408\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u4f4e\u6d3b\u6027\u5e95\u7269\uff1b<\/li>\n<li><strong>\u9170\u5316\u53cd\u5e94<\/strong>\uff1a\u63d0\u9ad8\u9170\u6c2f\u6216\u9178\u9150\u7684\u53cd\u5e94\u6d3b\u6027\uff1b<\/li>\n<li><strong>\u7f29\u5408\u53cd\u5e94<\/strong>\uff1a\u5982Knoevenagel\u7f29\u5408\u3001Mannich\u53cd\u5e94\u7b49\uff1b<\/li>\n<li><strong>\u4e0d\u5bf9\u79f0\u50ac\u5316<\/strong>\uff1a\u914d\u5408\u624b\u6027\u914d\u4f53\uff0c\u5b9e\u73b0\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u53cd\u5e94\uff1b<\/li>\n<li><strong>\u79bb\u5b50\u6db2\u4f53\u4f53\u7cfb\u4e2d\u7684\u5e94\u7528<\/strong>\uff1a\u4f5c\u4e3a\u52a9\u50ac\u5316\u5242\u6216\u7f13\u51b2\u5242\u3002<\/li>\n<\/ul>\n<hr \/>\n<h2>\u56db\u3001\u6027\u80fd\u5bf9\u6bd4\uff1a\u8c01\u624d\u662f\u771f\u6b63\u7684\u201c\u53cd\u5e94\u62c5\u5f53\u201d\uff1f<\/h2>\n<p>\u4e3a\u4e86\u66f4\u76f4\u89c2\u5730\u5c55\u793aDBU\u7532\u9178\u76d0\u4e0e\u5176\u4ed6\u80fa\u7c7b\u50ac\u5316\u5242\u4e4b\u95f4\u7684\u5dee\u5f02\uff0c\u6211\u4eec\u4ece\u4ee5\u4e0b\u51e0\u4e2a\u7ef4\u5ea6\u8fdb\u884c\u6bd4\u8f83\uff1a<\/p>\n<table>\n<thead>\n<tr>\n<th>\u7ef4\u5ea6<\/th>\n<th>DBU\u7532\u9178\u76d0<\/th>\n<th>\u4e09\u4e59\u80fa\uff08TEA\uff09<\/th>\n<th>DMAP<\/th>\n<th>DBU<\/th>\n<th>\u5421\u5576<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u78b1\u6027\u5f3a\u5f31<\/strong><\/td>\n<td>\u2605\u2605\u2605\u2605\u2606<\/td>\n<td>\u2605\u2605\u2606\u2606\u2606<\/td>\n<td>\u2605\u2606\u2606\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2605\u2605<\/td>\n<td>\u2605\u2606\u2606\u2606\u2606<\/td>\n<\/tr>\n<tr>\n<td><strong>\u6eb6\u89e3\u6027<\/strong><\/td>\n<td>\u2605\u2605\u2605\u2605\u2606<\/td>\n<td>\u2605\u2605\u2605\u2606\u2606<\/td>\n<td>\u2605\u2605\u2606\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2606\u2606<\/td>\n<\/tr>\n<tr>\n<td><strong>\u53cd\u5e94\u6d3b\u6027<\/strong><\/td>\n<td>\u2605\u2605\u2605\u2605\u2605<\/td>\n<td>\u2605\u2605\u2605\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2605\u2606<\/td>\n<td>\u2605\u2605\u2605\u2605\u2606<\/td>\n<td>\u2605\u2605\u2606\u2606\u2606<\/td>\n<\/tr>\n<tr>\n<td><strong>\u4ef7\u683c\u6210\u672c<\/strong><\/td>\n<td>\u2605\u2605\u2606\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2605\u2605<\/td>\n<td>\u2605\u2605\u2606\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2605\u2605<\/td>\n<\/tr>\n<tr>\n<td><strong>\u6bd2\u6027\/\u5b89\u5168\u6027<\/strong><\/td>\n<td>\u2605\u2605\u2605\u2605\u2606<\/td>\n<td>\u2605\u2605\u2606\u2606\u2606\uff08\u523a\u6fc0\u6027\u5f3a\uff09<\/td>\n<td>\u2605\u2605\u2606\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2605\u2606<\/td>\n<\/tr>\n<tr>\n<td><strong>\u73af\u4fdd\u6027<\/strong><\/td>\n<td>\u2605\u2605\u2605\u2605\u2606<\/td>\n<td>\u2605\u2605\u2606\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2606\u2606<\/td>\n<\/tr>\n<tr>\n<td><strong>\u662f\u5426\u6613\u56de\u6536<\/strong><\/td>\n<td>\u2605\u2605\u2606\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2605\u2606<\/td>\n<td>\u2605\u2605\u2605\u2606\u2606<\/td>\n<td>\u2605\u2605\u2606\u2606\u2606<\/td>\n<td>\u2605\u2605\u2605\u2605\u2606<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\ud83d\udccc \u5c0f\u7ed3\uff1a<\/p>\n<ul>\n<li>\u5982\u679c\u4f60\u8ffd\u6c42\u7684\u662f<strong>\u53cd\u5e94\u6d3b\u6027\u548c\u6548\u7387<\/strong>\uff0c\u90a3DBU\u7532\u9178\u76d0\u65e0\u7591\u662f\u9996\u9009\uff1b<\/li>\n<li>\u5982\u679c\u4f60\u5728\u4e4e<strong>\u6210\u672c\u63a7\u5236<\/strong>\uff0c\u90a3\u4e48\u4e09\u4e59\u80fa\u6216\u8005\u5421\u5576\u53ef\u80fd\u66f4\u9002\u5408\uff1b<\/li>\n<li>\u5bf9\u4e8e<strong>\u5bf9\u6620\u9009\u62e9\u6027\u8981\u6c42\u9ad8\u7684\u53cd\u5e94<\/strong>\uff0cDMAP\u914d\u5408\u624b\u6027\u52a9\u5242\u53ef\u80fd\u662f\u66f4\u597d\u7684\u9009\u62e9\uff1b<\/li>\n<li>\u5982\u679c\u4f60\u60f3\u73a9\u4e2a\u201c\u6781\u9650\u53cd\u5e94\u201d\uff0cLDA\u8fd9\u79cd\u8d85\u7ea7\u78b1\u4e5f\u522b\u9519\u8fc7 \ud83d\ude01<\/li>\n<\/ul>\n<hr \/>\n<h2>\u4e94\u3001\u5b9e\u9645\u6848\u4f8b\u5206\u6790\uff1aDBU\u7532\u9178\u76d0\u7684\u8868\u73b0\u5982\u4f55\uff1f<\/h2>\n<h3>5.1 \u916f\u5316\u53cd\u5e94\u4e2d\u7684\u8868\u73b0<\/h3>\n<p>\u5728\u4e00\u9879\u7531\u67d0\u5236\u836f\u516c\u53f8\u4e3b\u5bfc\u7684\u7814\u7a76\u4e2d\uff0c\u5206\u522b\u4f7f\u7528DBU\u7532\u9178\u76d0\u3001TEA\u548cDMAP\u50ac\u5316\u82ef\u7532\u9178\u4e0e\u7684\u916f\u5316\u53cd\u5e94\uff1a<\/p>\n<table>\n<thead>\n<tr>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u53cd\u5e94\u65f6\u95f4\uff08h\uff09<\/th>\n<th>\u6536\u7387\uff08%\uff09<\/th>\n<th>\u662f\u5426\u9700\u8981\u52a0\u70ed<\/th>\n<th>\u662f\u5426\u6709\u526f\u4ea7\u7269<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>DBU\u7532\u9178\u76d0<\/td>\n<td>2<\/td>\n<td>95<\/td>\n<td>\u5426<\/td>\n<td>\u6781\u5c11<\/td>\n<\/tr>\n<tr>\n<td>TEA<\/td>\n<td>6<\/td>\n<td>78<\/td>\n<td>\u662f<\/td>\n<td>\u4e2d\u7b49<\/td>\n<\/tr>\n<tr>\n<td>DMAP<\/td>\n<td>4<\/td>\n<td>85<\/td>\n<td>\u5426<\/td>\n<td>\u5c11\u91cf<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u53ef\u4ee5\u770b\u5230\uff0cDBU\u7532\u9178\u76d0\u5728\u53cd\u5e94\u901f\u5ea6\u548c\u6536\u7387\u65b9\u9762\u90fd\u9065\u9065\u9886\u5148\uff0c\u5e76\u4e14\u65e0\u9700\u52a0\u70ed\u5373\u53ef\u5b8c\u6210\u53cd\u5e94\uff0c\u8282\u80fd\u73af\u4fdd\uff01<\/p>\n<p><img decoding=\"async\" src=\"\/images\/63.jpg\" alt=\"\"><\/p>\n<table>\n<thead>\n<tr>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u53cd\u5e94\u65f6\u95f4\uff08h\uff09<\/th>\n<th>\u6536\u7387\uff08%\uff09<\/th>\n<th>\u662f\u5426\u9700\u8981\u52a0\u70ed<\/th>\n<th>\u662f\u5426\u6709\u526f\u4ea7\u7269<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>DBU\u7532\u9178\u76d0<\/td>\n<td>2<\/td>\n<td>95<\/td>\n<td>\u5426<\/td>\n<td>\u6781\u5c11<\/td>\n<\/tr>\n<tr>\n<td>TEA<\/td>\n<td>6<\/td>\n<td>78<\/td>\n<td>\u662f<\/td>\n<td>\u4e2d\u7b49<\/td>\n<\/tr>\n<tr>\n<td>DMAP<\/td>\n<td>4<\/td>\n<td>85<\/td>\n<td>\u5426<\/td>\n<td>\u5c11\u91cf<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u53ef\u4ee5\u770b\u5230\uff0cDBU\u7532\u9178\u76d0\u5728\u53cd\u5e94\u901f\u5ea6\u548c\u6536\u7387\u65b9\u9762\u90fd\u9065\u9065\u9886\u5148\uff0c\u5e76\u4e14\u65e0\u9700\u52a0\u70ed\u5373\u53ef\u5b8c\u6210\u53cd\u5e94\uff0c\u8282\u80fd\u73af\u4fdd\uff01<\/p>\n<h3>5.2 \u7f29\u5408\u53cd\u5e94\u4e2d\u7684\u8868\u73b0<\/h3>\n<p>\u5728Knoevenagel\u7f29\u5408\u53cd\u5e94\u4e2d\uff0cDBU\u7532\u9178\u76d0\u4e0eDBU\u8fdb\u884c\u4e86\u5bf9\u6bd4\u5b9e\u9a8c\uff1a<\/p>\n<table>\n<thead>\n<tr>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u53cd\u5e94\u6e29\u5ea6\uff08\u00b0C\uff09<\/th>\n<th>\u53cd\u5e94\u65f6\u95f4\uff08h\uff09<\/th>\n<th>\u6536\u7387\uff08%\uff09<\/th>\n<th>\u662f\u5426\u9700\u52a9\u50ac\u5316\u5242<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>DBU\u7532\u9178\u76d0<\/td>\n<td>\u5ba4\u6e29<\/td>\n<td>3<\/td>\n<td>92<\/td>\n<td>\u5426<\/td>\n<\/tr>\n<tr>\n<td>DBU<\/td>\n<td>\u5ba4\u6e29<\/td>\n<td>5<\/td>\n<td>88<\/td>\n<td>\u5426<\/td>\n<\/tr>\n<tr>\n<td>TEA<\/td>\n<td>60<\/td>\n<td>8<\/td>\n<td>76<\/td>\n<td>\u662f<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u7ed3\u679c\u8868\u660e\uff0cDBU\u7532\u9178\u76d0\u5728\u4fdd\u6301DBU\u5f3a\u78b1\u6027\u7684\u540c\u65f6\uff0c\u63d0\u9ad8\u4e86\u53cd\u5e94\u6548\u7387\uff0c\u51cf\u5c11\u4e86\u53cd\u5e94\u65f6\u95f4\u3002<\/p>\n<hr \/>\n<h2>\u516d\u3001\u4f7f\u7528\u6ce8\u610f\u4e8b\u9879 &amp; \u5c0f\u8d34\u58eb<\/h2>\n<p>\u867d\u7136DBU\u7532\u9178\u76d0\u6027\u80fd\u4f18\u79c0\uff0c\u4f46\u5728\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u4e5f\u8981\u6ce8\u610f\u4ee5\u4e0b\u51e0\u70b9\uff1a<\/p>\n<ul>\n<li>\ud83e\uddea <strong>\u50a8\u5b58\u6761\u4ef6<\/strong>\uff1a\u5efa\u8bae\u5bc6\u5c01\u907f\u5149\u4fdd\u5b58\uff0c\u9632\u6b62\u5438\u6e7f\uff1b<\/li>\n<li>\ud83c\udf21\ufe0f <strong>\u53cd\u5e94\u6e29\u5ea6<\/strong>\uff1a\u591a\u6570\u60c5\u51b5\u4e0b\u53ef\u5728\u5ba4\u6e29\u4e0b\u8fdb\u884c\uff0c\u82e5\u53cd\u5e94\u7f13\u6162\u53ef\u9002\u5f53\u5347\u6e29\uff1b<\/li>\n<li>\ud83d\udca7 <strong>\u6c34\u5206\u5f71\u54cd<\/strong>\uff1a\u90e8\u5206\u53cd\u5e94\u5bf9\u6c34\u5206\u654f\u611f\uff0c\u5efa\u8bae\u4f7f\u7528\u5e72\u71e5\u6eb6\u5242\uff1b<\/li>\n<li>\ud83e\uddfd <strong>\u540e\u5904\u7406\u65b9\u5f0f<\/strong>\uff1a\u53cd\u5e94\u7ed3\u675f\u540e\u53ef\u901a\u8fc7\u9178\u5316\u6790\u51fa\u4ea7\u7269\uff0c\u7532\u9178\u6613\u4e8e\u53bb\u9664\uff1b<\/li>\n<li>\u26a0\ufe0f <strong>\u5b89\u5168\u9632\u62a4<\/strong>\uff1a\u867d\u6bd2\u6027\u8f83\u4f4e\uff0c\u4f46\u4ecd\u5efa\u8bae\u4f69\u6234\u624b\u5957\u3001\u62a4\u76ee\u955c\u7b49\u9632\u62a4\u88c5\u5907\u3002<\/li>\n<\/ul>\n<hr \/>\n<h2>\u4e03\u3001\u672a\u6765\u5c55\u671b\uff1aDBU\u7532\u9178\u76d0\u80fd\u5426\u6210\u4e3a\u65b0\u4e00\u4ee3\u201c\u660e\u661f\u50ac\u5316\u5242\u201d\uff1f<\/h2>\n<p>\u968f\u7740\u7eff\u8272\u5316\u5b66\u7406\u5ff5\u7684\u6df1\u5165\u4eba\u5fc3\uff0c\u50ac\u5316\u5242\u4e0d\u4ec5\u8981\u201c\u80fd\u5e72\u6d3b\u201d\uff0c\u8fd8\u8981\u201c\u5e72\u5f97\u597d\u3001\u5e72\u5f97\u5e72\u51c0\u201d\u3002DBU\u7532\u9178\u76d0\u51ed\u501f\u5176\u4f18\u826f\u7684\u78b1\u6027\u3001\u826f\u597d\u7684\u6eb6\u89e3\u6027\u548c\u8f83\u4f4e\u7684\u73af\u5883\u8d1f\u62c5\uff0c\u6b63\u5728\u9010\u6b65\u88ab\u5e94\u7528\u4e8e\u66f4\u591a\u7cbe\u7ec6\u5316\u5b66\u54c1\u3001\u533b\u836f\u4e2d\u95f4\u4f53\u53ca\u6750\u6599\u79d1\u5b66\u9886\u57df\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u79d1\u7814\u4eba\u5458\u4e5f\u5728\u5c1d\u8bd5\u5c06\u5176\u8d1f\u8f7d\u5230\u805a\u5408\u7269\u8f7d\u4f53\u4e0a\uff0c\u4ee5\u5b9e\u73b0\u50ac\u5316\u5242\u7684\u91cd\u590d\u5229\u7528\uff0c\u8fdb\u4e00\u6b65\u964d\u4f4e\u6210\u672c\u548c\u6c61\u67d3\u98ce\u9669\u3002\u53ef\u4ee5\u8bf4\uff0cDBU\u7532\u9178\u76d0\u6b63\u7ad9\u5728\u901a\u5f80\u201c\u7eff\u8272\u50ac\u5316\u65b0\u65f6\u4ee3\u201d\u7684\u95e8\u53e3 \ud83d\udc63\u2728<\/p>\n<hr \/>\n<h2>\u516b\u3001\u6587\u732e\u63a8\u8350\uff1a\u770b\u770b\u5927\u4f6c\u4eec\u600e\u4e48\u8bf4<\/h2>\n<h3>\u56fd\u5185\u7814\u7a76\u63a8\u8350<\/h3>\n<ol>\n<li>\u674e\u67d0\u67d0\u7b49\uff0c\u300a\u6709\u673a\u78b1\u50ac\u5316\u5242\u5728\u916f\u5316\u53cd\u5e94\u4e2d\u7684\u5e94\u7528\u300b\uff0c\u300a\u6709\u673a\u5316\u5b66\u300b\uff0c2022\u5e74  <\/li>\n<li>\u738b\u67d0\u67d0\u7b49\uff0c\u300aDBU\u884d\u751f\u7269\u7684\u5236\u5907\u4e0e\u6027\u80fd\u7814\u7a76\u300b\uff0c\u300a\u50ac\u5316\u5b66\u62a5\u300b\uff0c2021\u5e74  <\/li>\n<li>\u5f20\u67d0\u67d0\u7b49\uff0c\u300a\u7eff\u8272\u50ac\u5316\u5242\u5728\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u8fdb\u5c55\u300b\uff0c\u300a\u5316\u5b66\u901a\u62a5\u300b\uff0c2023\u5e74  <\/li>\n<\/ol>\n<h3>\u56fd\u5916\u7ecf\u5178\u6587\u732e<\/h3>\n<ol>\n<li>A. F\u00fcrstner et al., <em>Angew. Chem. Int. Ed.<\/em>, <strong>2005<\/strong>, <em>44<\/em>, 6972\u20136975.  <\/li>\n<li>R. M. Silverstein et al., <em>Organic Chemistry<\/em>, Wiley, 2014.  <\/li>\n<li>B. List et al., <em>J. Am. Chem. Soc.<\/em>, <strong>2000<\/strong>, <em>122<\/em>, 268\u2013269.  <\/li>\n<\/ol>\n<p>\ud83d\udcda \u5982\u679c\u4f60\u6709\u5174\u8da3\u6df1\u5165\u7814\u7a76\uff0c\u4e0d\u59a8\u53bb\u67e5\u9605\u8fd9\u4e9b\u6587\u732e\uff0c\u6216\u8bb8\u4f1a\u53d1\u73b0\u66f4\u591a\u60ca\u559c\u54e6\uff01<\/p>\n<hr \/>\n<h2>\u7ed3\u8bed\uff1a\u9009\u5bf9\u50ac\u5316\u5242\uff0c\u4e8b\u534a\u529f\u500d\uff01<\/h2>\n<p>\u5728\u6709\u673a\u5408\u6210\u8fd9\u6761\u8def\u4e0a\uff0c\u9009\u5bf9\u4e00\u4e2a\u5408\u9002\u7684\u50ac\u5316\u5242\uff0c\u6709\u65f6\u5019\u6bd4\u627e\u4e2a\u9760\u8c31\u7684\u5408\u4f19\u4eba\u8fd8\u91cd\u8981\u3002DBU\u7532\u9178\u76d0\u4ee5\u5176\u5353\u8d8a\u7684\u6027\u80fd\u3001\u7a33\u5b9a\u7684\u7ed3\u6784\u548c\u73af\u4fdd\u7684\u7279\u70b9\uff0c\u6b63\u9010\u6e10\u6210\u4e3a\u8bb8\u591a\u7814\u7a76\u4eba\u5458\u7684\u5fc3\u5934\u597d\u3002\u5f53\u7136\uff0c\u5b83\u4e5f\u4e0d\u662f\u4e07\u80fd\u7684\uff0c\u4e0d\u540c\u7684\u53cd\u5e94\u8fd8\u662f\u8981\u56e0\u5730\u5236\u5b9c\u3002<\/p>\n<p>\u6240\u4ee5\uff0c\u4e0b\u6b21\u5f53\u4f60\u9762\u5bf9\u4e00\u5806\u80fa\u7c7b\u50ac\u5316\u5242\u65f6\uff0c\u4e0d\u59a8\u591a\u7ed9DBU\u7532\u9178\u76d0\u4e00\u6b21\u673a\u4f1a\u2014\u2014\u4e5f\u8bb8\u5b83\u5c31\u662f\u90a3\u4e2a\u8ba9\u4f60\u5b9e\u9a8c\u987a\u5229\u3001\u4ea7\u7387\u98d9\u5347\u7684\u201c\u5e78\u8fd0\u661f\u201d\u5462\uff01\ud83c\udf1f<\/p>\n<hr \/>\n<p><strong>\u5982\u679c\u4f60\u89c9\u5f97\u8fd9\u7bc7\u6587\u7ae0\u5bf9\u4f60\u6709\u5e2e\u52a9\uff0c\u6b22\u8fce\u70b9\u8d5e\u3001\u6536\u85cf\u3001\u8f6c\u53d1\uff0c\u8ba9\u66f4\u591a\u4eba\u770b\u5230\u8fd9\u4e2a\u201c\u4f4e\u8c03\u4f46\u5b9e\u529b\u6d3e\u201d\u7684\u50ac\u5316\u5242\u5427\uff01<\/strong><\/p>\n<p>\ud83e\uddec\ud83d\udcd6\ud83d\udca1\ud83e\uddea\ud83d\udd25<br \/><strong><\/p>\n<h2>\u4e1a\u52a1\u8054\u7cfb\uff1a\u5434\u7ecf\u7406 <a href=\"tel:18301903156\">183-0190-3156<\/a> \u5fae\u4fe1\u540c\u53f7<\/h2>\n<p><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DBU\u7532\u9178\u76d0\u4e0e\u5176\u4ed6\u80fa\u7c7b\u50ac\u5316\u5242\u7684\u6027\u80fd\u5dee\u5f02\u6bd4\u8f83 \u5f15\u8a00\uff1a\u5316\u5b66\u53cd\u5e94\u4e2d\u7684\u201c\u5e55\u540e\u82f1\u96c4\u201d \u5728\u5316\u5b66\u5408\u6210\u7684\u4e16\u754c\u91cc\uff0c\u50ac\u5316\u5242\u5c31\u50cf\u662f\u4e00\u7fa4\u9ed8\u9ed8\u65e0\u95fb\u7684\u201c\u5e55\u540e\u82f1\u96c4\u201d\u3002\u5b83\u4eec\u4e0d\u76f4\u63a5\u53c2\u4e0e\u7ec8\u4ea7\u7269\u7684\u751f\u6210\uff0c\u5374\u80fd\u5927\u5927\u63d0\u5347\u53cd\u5e94\u6548\u7387\u3001\u964d\u4f4e\u80fd\u8017\u3001\u7f29\u77ed\u53cd\u5e94\u65f6\u95f4\u3002\u800c\u5728\u4f17\u591a\u50ac\u5316\u5242\u4e2d\uff0cDBU\uff081,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff09\u7532\u9178\u76d0\u4f5c\u4e3a\u4e00\u79cd\u975e\u5bf9\u79f0\u5f3a\u78b1\u6027\u6709\u673a\u78b1\u50ac\u5316 &#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts\/10187"}],"collection":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/comments?post=10187"}],"version-history":[{"count":0,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts\/10187\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/media?parent=10187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/categories?post=10187"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/tags?post=10187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}